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What Are Bioreactors and Fermenters? Types, Differences & Applications Answering the core question: What are bioreactors and fermenters, and what is the difference between them? Bioreactors and fermenters are both sterile, instrumented vessels that grow living cells, but by convention a fermenter cultivates microorganisms (bacteria, yeast, fungi) — often under vigorous aeration for metabolite production — while a bioreactor emphasizes controlled aerobic cell culture,